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MARKER / KI-67

Ki-67 antibodies for IHC.

2 verified products currently listed.

Reviewed

What Ki-67 staining shows

Ki-67 is a nuclear protein associated with cells in active phases of the cell cycle. In immunohistochemistry, the proportion of stained nuclei can be reported as a labeling index for the cells assessed. The Working Group discusses interpretation of that percentage specifically in breast cancer.[1]

Why interpretation depends on context

The International Ki67 Working Group describes how specimen handling, staining, field selection, and scoring can affect reported results in breast cancer. Its recommendations and cutoffs are specific to that setting and should not be assumed to apply to other tumor types. The related Estrogen Receptor marker record is available for the breast-cancer context discussed in that guidance.[1]

Products in the ReagentScope catalogue

ReagentScope lists two separate verified Bio SB Ki-67 products: EP5 and RM360. Each clone has its own product record with manufacturer specifications and source information.[2][3]

References and sources

  1. Assessment of Ki67 in Breast Cancer: Updated Recommendations From the International Ki67 in Breast Cancer Working Group (scientific reference)
  2. Bio SB Ki-67 EP5 (PI5713) (manufacturer product information)
  3. Bio SB Ki-67 RM360 (PI3771) (manufacturer product information)